Crystalin Research
Our Services
Crystalin Research
API Characterization
Form Screen
PC/PK/PD Improvement
Phase Behavior
Computations
Patent Advice
Home Services Milestones Technical Labs Media Careers Contact Us

Milestones

Chalk2Salt Biz Plan, May 2010
UK-India Biotech-Pharma, Sep. 2010
Power of Ideas, Oct. 2010
Lab at TBI UOH, Nov. 2010
Member of MSME Cluster, Mar. 2011
Registration of Co., Mar. 2011
IKP Incubator, May 2011
Lab at LSI IKP, Nov. 2011
IKMC Poster Award, Nov. 2011
DBT-BIPP project on Pre-clinical trials of novel anticancer drug co-crystal, Jan. 2012
Biotech. Ignition Grant BIG on novel drug for Type II diabetes, Nov. 2012
Crystalin Research labs TBI-UOH recognized by DSIR, Mar. 2013
Soluble curcumin cocrystals funded by BIRAC-SBIRI, Dec. 2014


Ongoing Projects

Temozolomide
Chemotherapy for glioblastoma multiforme (GBM)
Primary malignant brain and CNS tumor
Approved for treatment of malignant glioma in US and EU in 1999. Patent expires in 2014
First drug licensed for treatment of malignant glioma in past 30 years
Temodar/ Temodal is Schering-Plough molecule
Discovered at Aston University in 1980s
TMZ prodrug. Active species is MTIC (CH3N2+)
White samples of temozolomide stored at 45% RH turned pink after 24 hours and the material was distinctly tan after 4 days indicating decomposition
There is a need to make stable Temozolomide form

Furosemide (Lasix)
Loop diuretic drug commonly used in the treatment of hypertension and edema.
BCS class IV drug. Solubility 6 mg/L in water and permeability log Pow 1.4
The highest dose strength of Furosemide is 80 mg, i.e. Do number of 53

Clotrimazole
Antimycotic imidazole effective against a wide range of fungal pathogens
Diverse biological actions
Effectively and rapidly inhibits growth of Plasmodium falciparum strains in vitro
Active against chloroquine sensitive strains and functions as effective antimalarial
But CLT has poor aqueous solubility (< 1 mg/L) and is hydrolyzed in acidic medium
Antimycotic imidazole effective against a wide range of fungal pathogens
Diverse biological actions
Effectively and rapidly inhibits growth of Plasmodium falciparum strains in vitro
Active against chloroquine sensitive strains and functions as effective antimalarial
But CLT has poor aqueous solubility (< 1 mg/L) and is hydrolyzed in acidic medium

Norfloxacin and Ciprofloxacin
Broad-spectrum antibacterial agents
Currently marketed solid dose of Norfloxacin is BCS Class IV
Fluoroquinone–COOH cocrystals of improved solubility and stability crystallized
© 2012 crystalin.co.in All Rights Reserved. Powered by ONS, Optimization by ShopaMagic